In December 1966, a group of 16 concerned parents and professionals from St. Louis and Springfield, Missouri met to discuss organizing an association for children with learning disabilities. In 1967, this group became the Association for Children with Learning Disabilities, acting under the bylaws and charters of the National Learning Disabilities Association.

Volunteers operated out of their homes and received modest grants, which eventually allowed them to open a small office in St. Louis in 1993. Over time, the organization grew, and in 2003, St. Louis LDA became an independent 501©3 organization and moved to its current location at 13537 Barrett Parkway in Ballwin.

St. Louis LDA has made an impact on over 31,000 children, parents & educators in the greater St. Louis area. 

As the only organization in the greater St. Louis community providing a comprehensive range of services to children with learning disabilities and/or ADHD, learning differences, Asperger's Syndrome, their parents and teachers, St. Louis LDA is funded solely by individuals, corporations, and private foundations.